Contents
Preface
xxPart 1. GENES AND CHROMOSOMES 1
Chapter 1. Genes Are DNA 2Chapter 2.
Genes Code for Proteins 26
Edited by Esther Siegfried, Pennsylvania State University, Altoona
Chapter 3. Methods in Molecular Biology andGenetic Engineering 42
Edited by John Brunstein, University of British Columbia
Chapter 4. The Interrupted Gene 79
Edited by Donald Forsdyke, Queens University
Chapter5. The Content of the Genome 98
Chapter 6. Genome Sequences and GeneNumbers 118
Chapter 7. Clusters and Repeats 139
Chapter 8. Genome Evolution 159
Chapter 9. Chromosomes 189
Edited by Hank W. Bass, Florida State University
Chapter 10. Chromatin 220
Part 2. DNA REPLICATIONAND RECOMBINATION 262
Chapter 11. The Replicon 263
Edited by Stephen D. Bell, Oxford University
Chapter 12. Extrachromosomal Replicons 282
Edited by Sgren Johannes Serensen & lars Hestbjerg Hansen, University of Copenhagen
Chapter 13. Bacterial Replication Is Connectedto the Ceil Cycle 299
Edited by Barbara Funnell, University of Toronto
Chapter 14. DNA Replication 320
Edited by Peter Burgers, Washington University Medical School
Chapter 15. Homologous and Site-SpecificRecombination 348
Edited by Hannah L. Klein & Samantha Hoot, New York University Langone Medical Center
Chapter 16. Repair Systems 391
Chapter 17. Transposable Elementsand Retroviruses 419
Edited by Damon Lisch, University of California,Berkeley
Chapter 18. Somatic Recombination andHypermutation in the Immune System 458
Edited by Paolo Casali, Institute for Immunology,University of California, Irvine
Part 3. TRANSCRIPTIONAN D POSTrRANSCRIPTIONALMECHANISMS 503
Chapter 19. Prokaryotic Transcription 504
Edited by Richard Gourse, University of Wisconsin, Madison
Chapter 20. Eukaryotic Transcription 546
Chapter 21. RNA Splicing and Processing 573
Edited by Xiang-Dong Fu, University of California,San Diego, School of Medicine
Chapter 22. mRNA Stability andLocalization 618
Edited by Ellen Baker, University of Nevada, Reno
Chapter 23. Catalytic RNA 642
Edited by Douglas ,7. Briant, University of Victoria
Chapter 24. Translation 665
Edited by Cheryl Keller Capone, Pennsylvania State University
Chapter 25. Using the Genetic Code 704
Edited by John Perona, University of California, Santa Barbara
Part 4. GENE REGULATION 734Chapter 26. The Operon 735
Edited by Liskin Swint-Kruse, University of Kansas School of Medicine
Chapter 27. Phage Strategies 767
Chapter28.Eukaryotic TranscriptionRegutation 795
Chapter 29. Epigenetic Effects AreInherited 828
Edited by Trygve ToUefsbol, University of Alabama, Birmingham
Chapter 30. Regutatory RNA 861
Gtossary 881
Index 905