生物化学

目 录内容简介
ContentsNotePrefaceIntroduction 1Chapter 1 Structures and Functions of Proteins 31.1 Amino Acid Compositionin Proteins 31.2 Molecular Structures of Proteins 61.3 Structure-Function Relationships of Proteins 141.4 Protein Physicochemical Properties and Principles of Purification 181.5 Proteome and Proteomics 22Summary 24Chapter 2 Structures and Functions of Nucleic Acids 262.1 The Structural Units of Nucleic Acids—Nucleotides 262.2 Structures and Functions of DNA 282.3 Structures and Functions of RNA 312.4 Properties of Nucleic Acids 342.5 Nucleases 362.6 Genomics and the Human Genome Project 37Summary 37Chapter 3 Enzymes 403.1 Structure and Function of Enzymes 403.2 Properties and Catalytic Mechanisms of Enzymes 423.3 Kinetics of Enzyme-Catalyzed Reactions 453.4 Regulation of Enzyme Activity 533.5 Nomenclature and Classification of Enzymes 553.6 Clinical Applications of Enzymes 56Summary 58Chapter 4 Carbohydrate Metabolism 604.1 Digestion and Absorption of Carbohydrates 604.2 Anaerobic Degradation of Glucose 614.3 Aerobic Oxidation of Glucose 644.4 Glycogen Formation and Degradation 694.5 Gluconeogenesis 734.6 Pentose Phosphate Pathway 764.7 Blood Sugar and Its Regulation 78Summary 80Chapter 5 Lipid Metabolism 815.1 Fatty Acids and Derivatives of Polyunsaturated Fatty Acids 815.2 Digestion and Absorption of Lipids 845.3 Metabolism of Fats 855.4 Metabolism of Phospholipids 945.5 Metabolism of Cholesterol 975.6 Metabolism of Plasma Lipoproteins 100Summary 106Chapter 6 Biological Oxidation 1096.1 Electron Transport Chain 1096.2 Oxidative Phosphorylation 1146.3 ATP and the Other High Energy Compounds 1186.4 Selective Transport across the Inner Mitochondrial Membrane 1196.5 Other Biological Oxidations 121Summary 122Chapter 7 Protein Catabolism 1237.1 Nutritional Roles of Dietary Proteins 1237.2 Digestion, Absorption and Putrefaction of Proteins 1247.3 Degradation of Proteins in Cells 1257.4 General Catabolism of Amino Acids 1267.5 Metabolism of Ammonia 1307.6 Individual Amino Acid Catabolism 133Summary 141Chapter 8 Nucleotide Metabolism 1438.1 Biological and Medical Functions of Nucleotides 1438.2 Degradation of Nucleic Acids 1448.3 Metabolism of Purine Nucleotides 1448.4 Metabolism of Pyrimidine Nucleotides 1478.5 Deoxyribonucleotide Biosynthesis 1508.6 Biosynthesis of Nucleoside Diphosphates and Nucleosides Triphosphates 1518.7 Dysmetabolism of Nucleotides and Antimetabolites 151Summary 153Chapter 9 Regulation of Metabolism 1559.1 Metabolic Regulationat Cell Level 1559.2 Metabolic Regulationat Hormone Level 1619.3 Regulation of Metabolismat Integral Level 162Summary 164Chapter 10 DNA Biosynthesis 16610.1 General Features of DNA Replication 16610.2 Eukaryotic DNA Replication 16810.3 Prokaryotic DNA Replication 17410.4 Other Modes of DNA Replication 17710.5 DNA Damage and Repair 179Summary 183Chapter 11 RNA Biosynthesis 18411.1 Overview of Transcription 18411.2 Transcriptionin Eukaryotes 18511.3 Processing of Eukaryotic RNA 18911.4 Transcriptionin Prokaryotes 19411.5 RNA-Dependent RNA Synthesis 197Summary 197Chapter 12 Protein Biosynthesis 19912.1 Machinery Involved in Translation 19912.2 Amino Acid Activation 20312.3 Protein Biosynthesis Journey 20412.4 Protein Posttranslational Modifications and Targeting 21112.5 Clinical Correlation of Protein Biosynthesis 216Summary 218Chapter 13 Regulation of Gene Expression 22013.1 General Characteristics of Gene Expression 22013.2 Regulation of Gene Expression in Prokaryotes 22213.3 Regulation of Gene Expression in Eukaryotes 227Summary 231Chapter 14 DNA Technology 23314.1 Genetic Engineering 23314.2 Molecular Hybridization 23914.3 Polymerase Chain Reaction 24214.4 DNA Sequencing 24514.5 Transgenesis, Animal Cloning and Gene Knockout Technologies 24614.6 Gene Diagnosis 24914.7 Gene Therapy 251Summary 253Chapter 15 Biomembranes 25515.1 Molecular Compositions of Biomembranes 25515.2 Structures of Biomembranes 25815.3 Transportation Functions of Biomembranes 26015.4 Biomembrane and Medicine 264Summary 266Chapter 16 Glycoproteins, Proteoglycans and Extracellular Matrix 26716.1 Structures and Functions of Glycoproteins 26716.2 Structures and Functions of Proteoglycans 27316.3 Extracellular Matrix 276Summary 279Chapter 17 Signal Transduction 28117.1 Signal Molecules 28117.2 Receptors 28217.3 Signal Transduction Pathways 28717.4 Interrelationship between Signal Transduction Pathways 29417.5 Signal Transduction and Medicine 294Summary 295Chapter 18 Oncogenes, Tumor Suppressor Genes and
目 录内容简介
《生物化学》是我国高等医学院校留学生本科教学和中、英双语教学班教学的生物化学教材,内容为医学专业学生应该掌握的基础理论、基本知识与基本技能,同时也兼顾了国家执业医师考试的要求。《生物化学》共21章,内容包括蛋白质、核酸和酶的结构与功能;糖、脂、氨基酸和核苷酸的代谢,以及生物氧化和代谢调节;DNA、RNA和蛋白质的生物合成,基因表达的调控及DNA技术;生物膜、糖复合物与细胞外基质、细胞信号转导,癌基因、抑癌基因与生长因子;肝胆、血液、维生素与无机物的生物化学。《生物化学》有插图348幅,表69个。《生物化学》特别注重在华留学生和双语教学的需要,重要的英文生化专业名词与术语均在其后标出相应的中文,并在书后附有名词释义,给出简洁、准确的概念。各章后均有中、英文内容摘要。
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